After 12-month follow-up, 22 patients had received appropriate ICD therapy. However, Tp–e increased significantly after CRT in patients with left bundle branch block or narrow QRS at baseline. ECG indices of dispersion of repolarization before and immediately after CRT implantation (QT dispersion, Tpeak–Tend, and Tp–e dispersion) were measured.In patients who were upgraded to a biventricular system, Tp–e did not increase significantly after CRT. Patients had symptoms of New York Heart Association functional class III or IV heart failure, left ventricular ejection fraction ≤35%, and QRS duration >130 ms or QRS ≤130 ms with left intraventricular dyssynchrony. The benefit of CRT on sudden cardiac death has been demonstrated only after 3 years follow-up.The purpose of this study was to explore the immediate effect of CRT on dispersion of repolarization and to define the value of dispersion of repolarization parameters as predictors of appropriate implantable cardioverter-defibrillator (ICD) therapy.Data from 100 patients who underwent CRT-ICD placement were analyzed retrospectively. The impact of cardiac resynchronization therapy (CRT) on dispersion of repolarization is controversial.
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